What are the Challenges in Establishing Physiological Relevance?
Several challenges exist in establishing physiological relevance:
Species Differences: Differences between species can complicate the extrapolation of animal study results to humans. Complexity of Biological Systems: Biological systems are inherently complex, making it difficult to predict how a toxicant will affect the system as a whole. Variability Among Individuals: Genetic and environmental factors can lead to significant variability in responses among individuals.
