What Are the Challenges in Mechanistic Understanding?
Despite its importance, achieving mechanistic understanding in toxicology faces several challenges. Biological systems are inherently complex, and toxic effects often result from multiple interacting pathways. Moreover, variability among individuals, such as genetic differences, can influence susceptibility to toxicants. These factors complicate the identification and analysis of mechanisms. Advances in omics technologies and systems biology are helping to overcome these challenges by providing comprehensive data and insights.
