Despite advances in science and technology, recognition in toxicology faces several challenges. One of the primary challenges is the vast number of chemicals in use today, many of which lack comprehensive toxicity data. Additionally, the complex interactions between different chemicals and their combined effects pose significant difficulties in accurately assessing mixture toxicity. Emerging contaminants, such as microplastics and per- and polyfluoroalkyl substances (PFAS), also present new challenges for recognition processes.