What Are the Challenges in Studying DNA Methylation in Toxicology?
Studying DNA methylation in toxicology presents several challenges. One major issue is the heterogeneity of methylation patterns across different tissues and cell types, making it difficult to draw generalized conclusions. Additionally, distinguishing between causative and correlative changes in methylation due to toxicant exposure requires sophisticated experimental designs and statistical analyses. The dynamic nature of methylation changes over time also adds complexity to studying its role in long-term exposure scenarios.
