What are the challenges in studying GPCRs in toxicology?
One of the main challenges in studying GPCRs is their structural complexity and diversity. With over 800 different types in humans, each GPCR can have unique binding sites and signaling mechanisms. This diversity makes it difficult to predict the toxicological effects of a substance that interacts with multiple GPCRs simultaneously. Additionally, GPCR signaling is highly context-dependent, varying with cell type and physiological state.
