What Are the Challenges in Using Analogous Compounds?
While analogous compounds provide valuable insights, there are challenges in relying solely on structural similarity for toxicity predictions. Even minor structural differences can lead to significant variations in pharmacokinetics and pharmacodynamics, resulting in unexpected toxic effects. Additionally, environmental and biological factors can influence a compound's behavior, complicating predictions based solely on analogous structures. Therefore, while analogous compounds offer a starting point, comprehensive toxicological testing is often necessary for accurate risk assessments.
