One of the main challenges of implementing Annex VI is the continuous need for updates and revisions as new scientific data becomes available. Keeping the classification list current requires significant resources and coordination among regulatory bodies, industry stakeholders, and scientific communities. Additionally, companies must stay informed about changes to ensure compliance, which can be resource-intensive, especially for small and medium-sized enterprises. Despite these challenges, the benefits of a harmonized classification system outweigh the difficulties associated with its implementation.