What Are the Common Teratogens Affecting Organogenesis?
Several substances have been identified as teratogens, which can cause congenital abnormalities during organogenesis. These include:
Alcohol: Can lead to Fetal Alcohol Spectrum Disorders (FASD), affecting brain and organ development. Thalidomide: Known for causing limb malformations when taken during pregnancy. Retinoic Acid: Excessive levels can result in craniofacial, heart, and central nervous system defects. Methotrexate: Used in cancer treatment, can cause multiple congenital abnormalities if exposed during pregnancy. Tobacco Smoke: Contains multiple toxicants that can impair fetal growth and organ development.
