The basic principles of toxicology revolve around several key concepts:
Dose-Response Relationship: The effect of a toxin is dependent on its dose. The relationship between the dose and the magnitude of the effect is a cornerstone of toxicological studies. Exposure: The manner and duration of exposure to a toxic substance significantly influence its toxicity. Exposure can be acute, chronic, or sub-chronic. Absorption, Distribution, Metabolism, and Excretion (ADME): These processes determine the internal dose of the toxin and its ultimate effect on the organism. Threshold: This is the dose below which no adverse effects are observed. Identifying the threshold helps in setting safe exposure limits.
