A deficiency or dysfunction in CFH can lead to uncontrolled complement activation, resulting in damage to host tissues. This has been implicated in conditions such as atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). In the context of toxicology, CFH deficiency can exacerbate the harmful effects of toxic chemicals and pollutants, leading to increased susceptibility to inflammatory and oxidative damage.
