What are the implications of drug metabolism in cystic fibrosis?
Drug metabolism can be significantly altered in individuals with CF due to differences in the expression of cytochrome P450 enzymes and other metabolic pathways. This can affect the efficacy and safety of medications, necessitating careful adjustment of drug dosages. For instance, CF patients may require higher doses of certain antibiotics due to faster clearance from the body, which underscores the need for personalized medicine approaches in CF treatment.
