Decongestants can interact with various other medications, potentially leading to dangerous effects. For instance, combining decongestants with monoamine oxidase inhibitors (MAOIs) can lead to hypertensive crises due to excessive vasoconstriction. Additionally, individuals taking antihypertensive drugs may find their effectiveness reduced when combined with decongestants. Therefore, it is essential to consult with healthcare providers before using decongestants alongside other medications.