The analysis of synovial fluid in a toxicological context typically focuses on several components:
Viscosity: Changes in viscosity can indicate inflammatory conditions. Toxins that affect protein structures can alter synovial fluid's viscosity. Cell Count and Differential: Elevated white blood cell counts may suggest infection or inflammation, possibly due to a toxic agent. Chemical Analysis: This involves measuring the levels of glucose, proteins, and uric acid, which can indicate metabolic disturbances. Microbial Culture: Identifying bacterial or fungal growth can point towards infection from toxin exposure. Crystals: The presence of crystals like calcium pyrophosphate or urate may indicate conditions such as gout or pseudogout, which can be exacerbated by certain toxins.
