What Are the Key Considerations in Biomaterials Toxicology?
Several factors are considered in biomaterials toxicology, including:
Chemical Composition: The chemical makeup of a material can influence its toxicity. For instance, heavy metals in implants might pose risks of systemic toxicity. Surface Properties: The surface characteristics of biomaterials, such as roughness and hydrophilicity, can affect protein adsorption and cell interaction, influencing biocompatibility and toxicity. Degradation Products: Biomaterials may degrade in the body, releasing byproducts. Assessing the toxicity of these byproducts is essential for ensuring long-term safety. Mechanical Properties: Mechanical mismatch between the biomaterial and the host tissue can lead to inflammation and other adverse biological responses.
