chromatographic techniques

What Are the Limitations of Chromatographic Techniques?

Despite their many advantages, chromatographic techniques have some limitations:
Sample Preparation: Often requires extensive sample preparation, which can be time-consuming and may introduce errors.
Cost: Equipment and maintenance costs can be high, especially for advanced systems like UPLC or GC-MS.
Matrix Effects: Biological matrices can interfere with the analysis, requiring careful method development and validation.

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