What are the Limitations of Graded Dose-Response Curves?
Despite their usefulness, graded dose-response curves have limitations. They often do not account for individual variability in response due to genetic, environmental, or physiological factors. Additionally, they primarily provide information about acute toxicity and may not adequately capture chronic effects or those that occur at very low doses. Moreover, these curves assume a direct correlation between dose and response, which may not always hold true in complex biological systems.
