What are the Limitations of Phage Display in Toxicology?
While phage display offers numerous advantages, it also has limitations. The technique can sometimes produce false positives, where peptides bind nonspecifically to targets. Additionally, the phage display system may not adequately mimic the complexity of interactions in living organisms, potentially leading to discrepancies between in vitro and in vivo results. Furthermore, the process of developing phage libraries and conducting biopanning can be time-consuming and resource-intensive.
