What Are the Limitations of Using Mice in Toxicology?
Despite their advantages, there are limitations to using mice in toxicology. One significant limitation is the genetic and physiological differences between mice and humans, which can affect the extrapolation of data. For instance, a compound might be toxic in mice but not in humans, or vice versa. Moreover, ethical concerns and the cost of maintaining laboratory mice are additional challenges. These limitations underscore the importance of complementing animal studies with in vitro and computational models.
