What Are the Limitations of Using Zebrafish in Toxicology?
Despite their many advantages, zebrafish are not without limitations in toxicology research. One significant limitation is the difficulty in administering certain types of chemicals that require metabolic activation in mammals. Additionally, while their genetic similarity to humans is notable, differences in metabolic pathways can lead to discrepancies in toxicity outcomes. Understanding these limitations is crucial for accurately interpreting data from zebrafish studies and applying them to human health risk assessments.
