What are the main neurotransmitters involved in CTZ activation?
Several neurotransmitters play a role in CTZ activation, including dopamine, serotonin, histamine, and acetylcholine. Dopamine (via D2 receptors) and serotonin (via 5-HT3 receptors) are particularly important, as they are common targets for antiemetic drugs used to treat nausea and vomiting associated with chemotherapy and other medical treatments. Understanding the involvement of these neurotransmitters helps in developing targeted therapies that can inhibit CTZ activation and prevent emesis.
