What Are the Mechanisms Behind Drug-Induced Angioedema?
Drug-induced angioedema primarily involves two pathways: histamine and bradykinin. Histamine-mediated angioedema is usually associated with allergic reactions, where mast cells release histamine due to an immunologic trigger. In contrast, bradykinin-mediated angioedema is associated with ACE inhibitors, where the breakdown of bradykinin is inhibited, leading to its accumulation and resultant swelling.
