What Are the Mechanisms of Toxicity Leading to Heart Failure?
The mechanisms by which toxins induce heart failure are complex and varied. They often involve oxidative stress, apoptosis, and disruption of calcium homeostasis. For instance, benzene can lead to the generation of reactive oxygen species (ROS), which damage cardiac cells. Additionally, some toxins may interfere with the normal functioning of ion channels, affecting the electrical activity of the heart.
