What are the Potential Toxicities Associated with G-CSF?
While G-CSF is generally well-tolerated, it can cause several adverse effects. Common side effects include bone pain, fatigue, and headaches. More serious but less common toxicities include splenomegaly and splenic rupture, acute respiratory distress syndrome (ARDS), and capillary leak syndrome. Long-term use may also pose a risk for myelodysplastic syndromes or acute myeloid leukemia, especially in patients with congenital neutropenia.
