What are the Toxicity Concerns of Antiarrhythmic Agents?
While these agents are essential in managing arrhythmias, they have a narrow therapeutic index, meaning the effective dose is close to the toxic dose. Toxicity can lead to serious side effects, including new or worsening arrhythmias, heart failure, and hypotension. Prolonged QT interval is a significant concern, as it can lead to a potentially fatal condition called Torsades de Pointes.
