What Are the Toxicological Effects of Phenylalanine in PKU?
The accumulation of phenylalanine in the brain leads to an array of toxicological effects. It can cause oxidative stress, disrupt neuronal function, and alter synaptic development. These changes are linked to intellectual disabilities, seizures, and mood disorders. The toxic effects are particularly severe in the developing brain, making early detection and treatment of PKU critical.
