What are the Toxicological Mechanisms of Fluorosis?
The toxicological mechanisms of fluorosis involve the accumulation of fluoride ions in the tissues, which interferes with various cellular processes. Fluoride affects the activities of enzymes, alters protein synthesis, and disrupts cellular signaling pathways. It replaces hydroxyl groups in the hydroxyapatite crystals of bones and teeth, leading to changes in their structure and function. Chronic exposure leads to mineralization defects and increased bone fragility.
