What challenges does JECFA face in its evaluations?
One of the challenges JECFA faces is the complexity of food matrices and the interactions between different chemicals present in food. The committee must consider the cumulative effects of multiple substances and their potential to cause harm. Additionally, the availability of data can be a limitation; some substances may lack comprehensive toxicological studies, making it difficult to assess their safety accurately. JECFA also needs to keep pace with emerging scientific knowledge and new technologies in toxicology.