Despite its success, the NTP faces several challenges. One major challenge is the vast number of chemicals that need to be tested for safety, which requires extensive resources and time. The program also grapples with the complexity of interpreting data from different types of studies, such as in vivo and in vitro results, and integrating them into a cohesive understanding of a chemical's toxicological profile. Additionally, there is a continuous need to develop and adopt new technologies and methodologies to enhance the efficiency and accuracy of toxicity testing.