An elevated anion gap can be caused by several conditions, including:
Ketoacidosis - Commonly seen in diabetic ketoacidosis where the body produces an excess of ketones. Lactic acidosis - Often due to hypoxia or shock, leading to increased lactic acid production. Renal failure - Resulting in the accumulation of sulfates and phosphates, contributing to the anion gap. Toxins - Such as methanol, ethylene glycol, and salicylates, which produce acidic metabolites.