What Factors Contribute to Variance in Toxicology?
Several factors contribute to variance in toxicological responses. These include:
Genetic variability: Differences in genetics can lead to varied expression of enzymes that metabolize toxicants, resulting in different levels of susceptibility. Age: Age can influence the absorption, distribution, metabolism, and excretion of chemicals, leading to different toxicological outcomes. Sex: Biological sex can affect hormone levels and metabolic rates, which can alter the body's response to toxicants. Environmental factors: Diet, lifestyle, and exposure to other chemicals can modify the effects of a toxicant. Health status: Pre-existing health conditions can exacerbate or mitigate the effects of chemical exposure.
