1. Genetic Variability: Differences in genetic makeup can lead to variations in enzyme expression and function, influencing an individual's susceptibility to toxins. 2. Environmental Factors: Exposure to certain chemicals, diet, and lifestyle can induce or inhibit enzyme activity. 3. Age and Gender: These intrinsic factors can affect enzyme levels and activity. 4. Disease States: Conditions like liver disease can significantly impact enzymatic function, altering the metabolism of toxins.
