Several factors can influence the systemic toxicity of a substance: - Dose: Higher doses generally increase the likelihood and severity of systemic effects. - Duration of Exposure: Chronic exposure often leads to more severe systemic effects than acute exposure. - Route of Exposure: The route by which the toxic substance enters the body can affect its distribution and impact. - Individual Susceptibility: Genetic factors, age, sex, and pre-existing health conditions can affect how an individual responds to a toxic substance.
