Central Nervous System (CNS) overstimulation refers to a state where the brain and spinal cord are overly activated, often due to exposure to certain toxic substances. This can lead to symptoms such as anxiety, agitation, muscle twitching, seizures, and in severe cases, coma. CNS overstimulation is a critical concern in toxicology, as it can result from exposure to a variety of substances including drugs, chemicals, and natural toxins.