Necroptosis is a programmed cell death pathway that is morphologically similar to necrosis, characterized by cell swelling, plasma membrane rupture, and subsequent inflammation. Unlike apoptosis, necroptosis is caspase-independent and is primarily mediated by the RIPK1, RIPK3, and MLKL signaling pathways. This form of cell death can be triggered by various stimuli, including TNF, interferons, and toll-like receptors.
