What is the clinical significance of CYP3A4 in toxicology?
In toxicology, CYP3A4 is significant due to its role in the metabolism of toxic substances. For instance, it is involved in the bioactivation of certain procarcinogens to their active carcinogenic forms. Understanding CYP3A4 activity is crucial for assessing the risk of toxicity and for developing strategies to mitigate adverse effects.
