What is the Genetic Basis of Paraoxonase Activity?
The activity of paraoxonase enzymes varies among individuals due to genetic polymorphisms. The PON1 gene, located on chromosome 7q21.3, has several polymorphic sites that affect enzyme activity levels. Two well-known polymorphisms are Q192R and L55M, which influence the enzyme's efficiency in detoxifying specific organophosphates. These genetic variations can affect an individual's susceptibility to organophosphate toxicity and pharmacogenomic profiles.
