What is the Pathophysiology Behind DRESS Syndrome?
The exact mechanism of DRESS syndrome is not completely understood, but it involves a complex interplay between drug metabolism, immune system dysfunction, and genetic factors. Some individuals may have a genetic predisposition that affects drug metabolism, leading to the accumulation of toxic metabolites that trigger an immune response. This can be further complicated by the reactivation of viral infections, such as human herpesvirus 6 (HHV-6).
