What Mechanisms Underlie Chemical-Induced Autoimmunity?
The mechanisms by which chemicals induce autoimmunity are complex and multifactorial. Some key pathways include:
- Molecular Mimicry: Chemicals may alter the structure of self-proteins, making them resemble foreign antigens, which the immune system then attacks. - Altered Immune Regulation: Certain chemicals can disrupt immune cell regulation, leading to an inappropriate immune response. - Inflammatory Pathways: Exposure to toxins can trigger chronic inflammation, which can contribute to the development of autoimmune diseases.
