What Role Does Age Play in Toxicological Variability?
Age is a critical factor in toxicological variability, as it influences the body's ability to absorb, distribute, metabolize, and excrete chemicals. Pediatric populations are often more vulnerable to toxicants due to their developing organ systems and metabolic pathways. Conversely, older adults may experience increased toxicity due to age-related declines in organ function and slower metabolic rates. These age-related differences necessitate age-specific risk assessments and regulatory guidelines.
