What Role Does Bile Play in Enterohepatic Circulation?
Bile is integral to the enterohepatic circulation of certain drugs and toxins. After being secreted into the intestine, some bile components, including bile acids and certain toxins, can be reabsorbed into the bloodstream and returned to the liver. This recycling process can prolong the presence of a toxic substance in the body, potentially increasing its toxic effects. Understanding this cycle is crucial for predicting the pharmacokinetics and potential toxicity of certain compounds.
