Several medications are metabolized via the glucuronidation pathway, and individuals with Gilbert's syndrome may exhibit different responses to these drugs. For example, irinotecan, a chemotherapy drug, is metabolized into an active form that is subsequently inactivated by glucuronidation. Patients with Gilbert's syndrome may experience increased toxicity from irinotecan due to impaired glucuronidation. Other drugs potentially affected include paracetamol (acetaminophen), rifampicin, and certain antiviral agents.
