How Do Tyrosine Kinases Contribute to Drug Metabolism and Resistance?
Tyrosine kinases are also involved in drug metabolism and can contribute to drug resistance. They can modulate the expression and activity of drug-metabolizing enzymes, affecting the pharmacokinetics of various compounds. Additionally, mutations in tyrosine kinases can lead to resistance against TKIs, necessitating the development of second-generation inhibitors and combination therapies. Research in this area helps in designing better therapeutic strategies and understanding the toxicological implications of drug interactions.
