Which Interleukins are Most Relevant in Toxicology?
Several interleukins are particularly relevant in toxicology due to their roles in inflammation and immune regulation:
Interleukin-1 (IL-1): A pro-inflammatory cytokine that is often elevated in response to toxic injury. It plays a role in fever production and the acute phase response. Interleukin-6 (IL-6): Another pro-inflammatory cytokine involved in the acute phase response, IL-6 is often upregulated in response to toxins and can be a marker of inflammation. Interleukin-10 (IL-10): An anti-inflammatory cytokine that helps regulate the immune response and prevent excessive tissue damage. Interleukin-17 (IL-17): Involved in the recruitment of neutrophils and other immune cells to sites of inflammation, IL-17 can contribute to both protective and pathological responses to toxins.
