In silico models play a crucial role in modern toxicology for several reasons: 1. Reduction in Animal Testing: They help in reducing the reliance on animal testing, aligning with ethical considerations and regulatory requirements. 2. Cost-Effectiveness: These models are significantly cheaper compared to experimental methods. 3. Speed and Efficiency: Computational models can rapidly screen thousands of chemicals, expediting the risk assessment process. 4. Regulatory Acceptance: Regulatory bodies like the ECHA and the EPA increasingly recognize in silico models for chemical safety evaluations.