The choice of using median over mean in toxicological assessments is often due to the nature of the data. Toxicological data can be highly skewed, with a few high-dose responses heavily influencing the mean. The median, by contrast, remains unaffected by these extreme values, offering a more stable and reliable measure of central tendency. This is particularly important in regulatory toxicology, where decisions about safety thresholds and permissible exposure limits are made based on such statistical analyses.
