Several factors contribute to drug accumulation, including:
Half-life: Drugs with a long half-life are more prone to accumulation because they remain in the body longer. Dosing Frequency: Frequent dosing without adequate elimination time can lead to accumulation. Metabolic Rate: A slower metabolism may reduce the rate at which a drug is cleared, increasing accumulation risk. Drug Interactions: Other medications can inhibit or compete with the metabolism of a drug, affecting its clearance.
