In toxicology, HTS is essential for several reasons: - Early Detection of Toxicity: HTS can screen thousands of compounds rapidly, identifying potential toxic effects before they reach later stages of development. - Efficiency: The automation and miniaturization of HTS significantly speed up the process, making it possible to evaluate a vast number of compounds in a short period. - Cost-Effectiveness: By identifying toxic compounds early, HTS helps in reducing the cost associated with late-stage drug development failures.