Why is It Important to Recognize Zero Order Kinetics?
Recognizing zero order kinetics is essential because it affects the predictability of drug clearance and the half-life estimation. In zero order kinetics, the half-life is not constant and depends on the initial concentration. This unpredictability can lead to complications in dosing regimens and increases the risk of toxicity. Clinicians must be aware of this when prescribing medications that follow zero order kinetics, especially in populations with compromised metabolism, such as those with liver disease.
