While many anions are involved in essential physiological functions, some can be toxic at high concentrations. For instance, fluoride (F-) is beneficial for dental health in small amounts but can cause skeletal fluorosis if consumed in excess. Similarly, high levels of nitrate in drinking water can lead to methemoglobinemia, also known as "blue baby syndrome," a serious condition in infants. Thus, understanding the balance and regulation of anions is crucial in toxicological assessments.