The safety profile of GLP-1 receptor agonists is generally considered favorable, but like any pharmacological agent, they are not without risks. Common adverse effects include gastrointestinal disturbances such as nausea and vomiting. These side effects are usually transient and decrease over time with continued use. In toxicology, understanding the dose-response relationship is crucial. At therapeutic doses, GLP-1 RAs are safe for most patients, but higher doses can increase the likelihood of adverse effects.